West Midlands Mayor Andy Street has urged MPs to back Theresa May's Brexit deal.
And he said rejecting the deal, when the Commons holds an historic vote on December 11, would put the prosperity of the West Midlands at risk.
He said: "I hope that MPs in the region will put aside party politics, and pluck up the courage to vote in the interest of the people of the West Midlands."
MPs are to hold a "meaningful vote" on whether or not to accept the proposed withdrawal agreement negotiated between the UK Government and the EU.
But it appears that many Conservative MPs are planning to vote against the deal. Labour will also vote against it, which means that Government could face defeat.
It's unclear what would happen next. Possibilities include leaving the EU without any deal at all, holding a second Brexit referendum (sometimes called a People's Vote) or having a general election.
Mr Street said MPs should vote to accept the withdrawal agreement. He said: "The deal with the EU secures much of what people in the West Midlands voted for.
We will no longer be under the jurisdiction of the European Court of Justice, we will be able to set an immigration policy which works for our people and our economy, and our manufacturers like Jaguar Land Rover will be able to trade with Europe freely and easily.
"This access is vital when 25% of their finished cars go to Europe and 40% of their suppliers are in Europe. With our future trading arrangements, these companies will be able to sell more to growing markets across the world. It will, in short, secure thousands of jobs for the long term.
"In the coming months, there are details which will be worked through, but on the substantive points, this deal works for the West Midlands."
He said Theresa May had been "pragmatic, business-friendly, and doggedly determined in her negotiations".
And he said the West Midlands was enjoying economic success which could now be put at risk.
"We are seeing significant economic success in the West Midlands, in a way which we have not for forty years. For the UK to succeed, the West Midlands must succeed.
"Let us not put it all at risk by hoping for the perfect deal."
While the Labour front bench will oppose the Government's Brexit deal, some backbench Labour MPs could ignore instructions from the leadership and vote for it.
Dudley North Labour MP Ian Austin said in an article published by the Guardian: "It is clearly not a perfect deal, but there was never going to be a perfect deal.
"My constituents voted to leave. They expect us to sort this out and we in the Labour party need to think carefully before rejecting it."