It's the West Midlands tourist attraction which draws in thousands of visitors every year from across the world.
And now Shakespeare's Birthplace, in Stratford-upon-Avon, has been named as one of the UK's top ten music and literature buildings alongside legendary venues such as Abbey Road Studios and the Hacienda.
Campaign group Historic England is running a project called 'A History of England in 100 Places' with ten different categories, each featuring ten interesting and important buildings.
A citation by Historic England said: "Although we're not sure of the exact date, this is believed to be the house in which William Shakespeare, the world's most famous writer, was born in 1564.
"It was here in Stratford that he lived with his wife Anne Hathaway and three children before he left around 1585.
"Within a few years he was an established playwright in London, penning at least 38 plays and over 150 poems before his death at the age of 52."
Author Monica Ali, who judged the category, added: "How could it not be included?
"Shakespeare is the greatest English language writer, the most important dramatist and a superb poet.
"A visit to his birthplace and to the Royal Shakespeare Company is always inspiring."
Among the other venues in the music and literature category are the former homes of novelists Charles Dickens and George Orwell in London, Chetham's Library in Manchester and the Brontë Parsonage in West Yorkshire.
Last year, a row of prefab bungalows built in Moseley after the Second World War was selected by Historic England to be included in the list in the homes and gardens category.
The properties were only meant to last for ten years but 16 units were awarded grade II-listed status in 1998.
Ms Ali added: "I was intrigued by the idea of telling the history of England in 100 places.
"The judging process proved to be a reminder of just how rich the nation's history of creativity is and it was tough to select only ten places.
"Why is it important to celebrate such places?
"It is an acknowledgement of how the arts have shaped our society.....these are not only places in which to learn about the past, they also invite contemplation, reflection and - just maybe - inspiration."