Transport leaders from across the region have welcomed the decision to bring forward the opening of the HS2 line north of Birmingham as well as the confirmation of new stations.
The Midlands Connect Partnership, which is lobbying for better east-west rail links across the region, also welcomed the confirmation of new HS2 stations - at Toton, serving Nottingham and Debry, and at Crewe, serving Stoke.
It means the Midlands would be served by four stations in total.
The city centre Curzon Street station and Birmingham Interchange, close to the National Exhibition Centre in Solihull, had previously been confirmed as part of phase one of the high speed rail line between London and city.
The Midlands Connect Partnership, which includes 11 local enterprise partnerships and 26 transport authorities, has restated its determination to make HS2 work for the region by putting in place the transport links needed to secure the maximum economic benefits possible from the line.
Chairman of the Midlands Connect leaders Group Sir Albert Bore said: "The announcement that the Midlands is set to be served by four HS2 stations is tremendous news.
"Midlands Connect will now work with government to make sure our wider transport network is properly connected to these stations and, by doing so, reap the maximum economic benefits possible from HS2.
"We are already making good progress on this front. Plans are well advanced for the two phase one stations with tram and rail links planned along with schemes to develop surrounding land with the Birmingham Curzon HS2 Masterplan and the UK Central project.
"We now need to make sure the stations at Toton and Crewe are also properly connected and developed so we can unlock further growth and jobs."
Midlands Connect is already working with the Department for Transport on developing a region-wide transport strategy that can drive the economy and power the Government's ambition to build a Midlands Engine for Growth.
The Government is also putting £1.25 million towards the development of an East Midlands HS2 Growth Strategy and a further £600,000 towards the regeneration scheme around the HS2 station at Crewe.
Vice-chairman Jon Collins added: "An HS2 hub station at Toton will make a major contribution to the Government's Midlands Engine initiative, and the quicker we can build it the better."
Initial research carried out by Midlands Connect has shown that better road and rail links to speed up journey times across the region could boost the regional economy by more than £1 billion a year, create 300,000 additional jobs and save businesses nearly £500 million.
With ten million people, 14 cities, 20 universities and an annual contribution to the British economy of more than £178 billion a year, the Midlands offers unparalleled economic opportunities.
But it also suffers significant transport challenges which impact on its competitiveness and that of the wider UK economy.
The strategic plan being developed will aim to tackle those transport constraints in order to unlock growth opportunities and capitalise on HS2.