The Prime Minister has pledged that a future Conservative government will back West Midland manufacturers and make sure at least three out of every five new jobs are created outside London and the South East.
The Conservative leader said the aim was to ensure fairness and economic growth across the whole of the UK while accusing Labour of neglecting the Midlands and the North when it was in power.
He said they were content for new jobs to be concentrated in the south of England.
Tories highlighted research which showed nine out of ten private sector jobs between 1998 and 2008 went to London, the south or the east of England.
Mr Cameron also announced plans for an annual review of the impact of Scottish devolution, to ensure handing more powers over to the Scottish Parliament had not disadvantaged the English regions.
And he highlighted proposals, previously announced, to review the impact on English regional airports of the Scottish Government's new powers to cut Air Passenger Duty.
The focus on backing the English regions comes as the Tories prepare to launch a series of regional manifestos setting out their plans to support employers and create jobs in every part of the country.
Mr Cameron said the Conservatives had created two million jobs over the last five years - and have made a commitment to create another two million by 2020.
And he boasted that, over the last five years, 61.5 per cent of the two million jobs created had been outside London and the South East.
He said: "I didn't come into this to create some reckless, booming economy just within the M25. That's what we had before.
"In Labour's Britain, where for every ten private sector jobs created in the South, just one was created in the North and the Midlands."
He added: "No more. We will back business to create two million new jobs. And this is my goal - that more than 60 per cent of these will be outside London and the South East. That is what we've done in the last Parliament.
"Because my vision has always been of a truly balanced economy, one built to last - one which is seen not just on the screens of the traders in the City of London but in the great manufacturing plants of the West Midlands and North East; in tech start-ups from Dundee to Manchester; in the tourist and defence industries of the South West and Wales, the life sciences labs of the East of England - a truly national recovery."
Conservatives highlighted a study by think tank the Centre for Cities which found the number of private sector jobs in London rose by 288,500 between 1998 and 2008, and the number in the South East rose by 145,400.
But in the West Midlands, the number of private sector jobs actually fell by 65,600 between 1998 and 2008.
Including the east of England and South West of the country as the "south", the think tank said in its report: "For every extra private sector job generated in the North and Midlands between 1998 and 2008 ten were created in London and the South."
A Labour spokesman said: "David Cameron is in a panic as the wheels come off the Tory election campaign.
"He has nothing to offer the working people of Britain of any substance - there's nothing new in this announcement today.
"Labour has already said that the implementation of the Smith Commission will need to ensure that the English regions do not lose out, for example on Air Passenger Duty. That remains the case."
Birmingham Airport has warned that giving Scotland the power to cut Air Passenger Duty without introducing a similar cut in the North East would have a "potentially damaging impact" on its business.
An open letter published by Birmingham Airport chief executive Paul Kehoe, alongside the heads of Bristol and Newcastle airports in November 2014, said: "Air Passenger Duty is a tax that should be reformed via UK-wide abolition, reduction or via measures to encourage all regional airports to flourish, not by opening up market distortions between constituent parts of the UK."
The battle for power
Our interactive poll-of-polls draws on every opinion poll published by each of the main polling companies over the last 100 days: