Leader Natalie Bennett will deliver the opening speech on Friday afternoon with the conference running until September 8.
Workshops will run throughout all four days to give members the opportunity to come together to discuss and set party policy.
This is the first time the party has chosen to host its annual conference at a residential venue and it will serve as an economic boost for both Aston University, of which host venue Conference Aston is a subsidiary, and local businesses.
Nearby pub Gosta Green is due to host an open mic night on Sunday for attendees.
Conference Aston was chosen for its green credentials as it was the first academic venue in the United Kingdom to be ISO14001 accredited.
Lucy Talbot, director at Conference Aston, said: "To get the Green Party to hold their annual conference here is not only a coup for us but also for Birmingham.
"Outside of London, this is the most popular destination for meetings and conferences and events the size of this only help to reinforce this position.
"One of the main influences during our recent £5.4 million refurbishment was to ensure that we made the venue as sustainable and green as possible.
"As a result, we've managed to secure the booking of the biggest green organisation in Europe."