Robert Koren produced an inspired display to help West Brom move off the bottom of the Barclays Premier League - and drag Gareth Southgate's side further into the relegation mire.
The Slovenian international set up one goal for debutant Marc-Antoine Fortune and scored another himself after Chris Brunt had made an early breakthrough.
It enabled Albion to complete their first ever Premier League double after a 1-0 win at the Riverside Stadium earlier in the season and means Boro have now gone 10 league games without a win.
West Brom fans taunted Southgate with cries of 'you're getting sacked in the morning' and to add to Boro's misery, midfielder Didier Digard was red-carded after 63 minutes for a challenge on Borja Valero.
It might have been a different story had not Boro striker Afonso Alves squandered four good opportunities.
But Albion also posed a constant threat and on loan Arsenal striker Jay Simpson again impressed with his skill, pace and work-rate.
Tony Mowbray's side looked doomed to the drop a month ago and in danger of being cut adrift at the bottom after a 10-game run without a win.
But a hat-trick of home successes against Manchester City, Tottenham and Boro have revived their fortunes.
Brunt put the Baggies in front after only four minutes.
Boro defender Tony McMahon failed to make proper contact with a clearance header from a deep cross by Carl Hoefkens and the ball broke to Brunt.
The former Sheffield Wednesday drilled in a low shot which took a slight deflection off McMahon before flying past Ross Turnbull into the corner of the net.
Boro tried to retaliate and only the woodwork denied Alves an equaliser three minutes later.
Scott Carson was at full stretch in palming away a deep centre from acting Boro
skipper Stewart Downing and the ball broke to Alves who headed against the crossbar.
Alves then missed a good chance after 24 minutes after David Wheater had flicked on a floated free-kick from Taylor.
The ball dropped down onto the right foot of the ?12million signing but he volleyed wide.
But after 27 minutes Simpson should have doubled Albion's lead. He raced clear of the Boro defence after beating the offside trap to seize onto a pass from Ryan Donk.
He found himself with only Turnbull to beat but his touch was slightly heavy and the keeper was able to block his eventual shot.
Brunt also had a good chance to grab his second goal when he got on the end of a centre from Hoefkens but glanced his header wide of the far post.
Boro were forced to make a change at the back after 36 minutes when Chris Riggott limped out of the action to be replaced by Robert Huth.
Carson came to West Brom's rescue when he beat away a powerful drive from Alves after he had cut in from the left flank while Turnbull saved a low shot from a narrow angle by Fortune with his feet.
It was Albion's turn to make an enforced defensive change when Leon Barnett made way for Pele after 39 minutes.
Simpson was continuing to look a threat for Albion and he came close to increasing their lead early in the second half.
Fortune showed good skill on the touch-line before picking out the run of Simpson deep in the Boro half. He cut inside and curled a left-footed shot from 15 yards out just wide with Turnbull well beaten.
But then after 54 minutes Albion doubled their lead through Fortune's first goal for the club - although he knew little about it.
Koren was the creator with a run into the box before dinking the ball into the feet of Fortune.
He held the ball up well before turning it back to Koren and then inadvertently deflected the shot from the Slovenian international past Turnbull.
Southgate responded by taking off O'Neil and replacing him with Mido and the former Tottenham player set up another great chance for Alves.
Again he failed to take advantage by heading wide from six yards out.
The chances continued to come thick and fast with Turnbull denying Simpson before Boro were reduced to 10 men after 63 minutes.
Referee Mark Halsey produced an instant red card after a challenge by Digard on Valero although replays suggested it may have been a harsh decision.
After 66 minutes Koren capped an excellent individual display by scoring Albion's third goal. He made another surging forward run to seize on a pass from Brunt and coolly knocked his shot wide of Turnbull.