Matthew Upson's absence from Birmingham's critical clash with Sunderland will come as a hammer blow to Steve Bruce.
In a season where Bruce has been on the receiving end of some meaty right hooks from the hand of fate, Upson's groin injury is particularly untimely.
The only consistent aspect about Blues' season thus far has been their injury list; there has been no half measures where ailments are concerned and the thin blue line are the latest recipients of glum tidings.
If it wasn't a rash of left-backs, it was a gaggle of midfielders all crammed into the treatment room.
Just when the clouds appeared to have lifted, Bruce was left with one man standing in attack and now his defence have taken up the cudgels.
Upson, Kenny Cunningham, Olivier Tebily and Alex Bruce are all unavailable for today's game with Martin Taylor a major doubt.
Yet more concerns for Bruce on an afternoon where the tension is tangible.
"It is the biggest game of the season so far, but only because we have made it that way," lamented Upson.
"Every game will now become our biggest of the season.
"Given the current situation, this is most pressure on us to win a football match this season.
"If we do, it gives us a psychological lift; especially going into games against Middlesbrough and Albion.
"These next three games are going to be vital to our Premiership survival."
There has even been talk of Chris Sutton making an emergency appearance at centre-half given the lack of numbers at Bruce's disposal in that department.
Nevertheless, the log-jam in Birmingham's treatment room is gradually easing, which bodes well for the final 13 Premiership fixtures.
And it begs the question; with a fully fit squad all season, just where would Birmingham be in the Premiership table?
"We would be pretty healthy position," answered Upson. "Definitely not in the bottom three.
"It tells you something about the injury situation at the club and where we are at.
"Maybe we need to ask why aren't' we getting more out of the squad that we have?
"I don't know what we more could have been done with our injuries though.
For instance, Muzzy Izzet has been struggling since he received a really bad blow to his knee which formed a loose particle.
"Ever since then he has been chasing his tail a little bit.
"Mikael Forssell has had an ongoing problem with his knee since he went back to Chelsea and we wanted to take him because we saw how well he did for us.
"He is getting there, but hasn't quite found his feet with fitness yet.
"David Dunn has had major back surgery as well. It is difficult to gauge what you can do in situations like that.
"Being unlucky with injuries is one of the factors why we are in the bottom three."