Top seed and 2004 Wimbledon Champion Maria Sharapova could face a difficult third round match-up against Eleni Daniilidou after the draw was made for the DFS Classic, which begins at Edgbaston Priory today.
The Greek star is one of the most feared opponents on grass and stretched Sharapova to the limit in the quarter-finals last year before going on to remove Justine Henin-Hardenne at Wimbledon.
Two-time defending champion Sharapova opens her campaign against a qualifier or Stephanie Foretz of France. Daniilidou is scheduled to meet British No 1 Anne Keothavong in the opening round, who benefited from one of four wildcards offered to British players.
British No 3 Katie O'Brien takes on 16-year-old Japanese junior Ayumi Morita while Sarah Borwell and Melanie South will square off in an all British opening round contest.
Sharapova is scheduled to meet Japan's 5th seed Ai Sugiyama in the quarterfinals with last year's runner-up eighth seed Jelena Jankovic a potential semi-final opponent.
London-based Italian Francesca Schiavone is the second seed. The world No 12 is making her first visit to Edgbaston in four years and faces either Maria Vento-Kabchi or Antonella Serra Zanetti in the second round after a first round bye.
Popular Slovakian Daniela Hantuchova is this year's third seed and could face Surbiton champion Kristina Brandi in the second round.
Lying in wait in the third round could be rising Indian sensation Sania Mirza. The 19-year-old from Hyderabad is already a superstar back home and will be a popular figure at this year's DFS Classic.
The other highlight of opening round action features a battle between two former top-ten stars as Australian Alicia Molik goes head-to-head with Russian Vera Zvonareva. Molik will be playing only her fourth tournament following a six-month sabbatical from the game to recover from an inner ear infection (vestibular neuronitis) that affected her vision and balance.
British junior No 1 Naomi Cavaday narrowly failed in her bid to qualify for the main draw after she lost a tight match 3-6, 7-5, 7-5 to world No 85 Melinda Czink of Hungary.
Cavaday, aged 17, from Chislehurst in Kent, looks set to move up from her current rank of 565 following her first round victory.
Martina Navratilova has withdrawn from the doubles competition at Edgbaston.
That means the field is now headed by the world No 2 doubles team of Cara Black from Zimbabwe and Rennae Stubbs from Australia and the Olympic champions from Athens 2004, Ting Li and TianTian Sun of China.