Communications, property and industry are the main catalysts for the privileged 50 featured in The Birmingham Post Rich List today.
The list also heralds the work, creativity and inspiration of the region's entrepreneurs and businessmen who have carved out personal fortunes through their endeavours.
Among the billionaires and multi-millionaires are Phones4U owner John Caudwell, developers Don and Roy Richardson, Viscount Portman, JCB's Sir Anthony Bamford and Birmingham City Football Club co-owner David Sullivan.
* Get your hands on a copy of the 2006 Midland Rich List only in today's Birmingham Post - on sale now *
Andy Skinner, who compiled the rich list, said: "If you are looking for a foundation to build on, then look no further than property for your wealth.
"An overwhelming number of millionaires in the Midlands Rich List have either made their money in property or successfully invested in property."
Tony Lennox, acting editor of The Birmingham Post, said the list highlighted the entrepreneurial talent in the region.
He said: "Historically, the men and women of the Midlands have earned their wealth through hard work and creativity - and their wealth creation has traditionally brought benefits to the people of the region.
"It's good to see that these principles appear to still hold true."