Labour councillors have written to the Health Secretary urging the Government to back Birmingham's £559 million new super-hospital.
Councillor Jan Drinkwater (Weoley), along with six of her Labour colleagues who have constituencies near the proposed site of the hospital, wrote to Patricia Hewitt asking the Government to get behind the plan now to avoid additional costs.
The ambitious project will replace the existing Queen Elizabeth, Selly Oak and QE Psychiatric hospitals.
Already £30 million has been spent preparing the site but the only building completed so far is a new £12 million multi-storey car park. The work is in danger of coming to a halt if the Treasury fails to make a decision soon over whether the trust - which runs the existing hospitals - can go ahead with its plans.
Coupled with a £325 million Sainsbury's development in Selly Oak, plus and additional £40 million invested by the supermarket, city council and trust to build new roads, this will be Birmingham's largest act of urban regeneration, costing nearly £1 billion.
In order to sign new contracts allowing more foundation works to go ahead, the scheme needs the Government's agreement to pick up the tab if University Hospital Birmingham goes bust.
The letter spells out to the Government just how important regeneration is in the area in the wake of the collapse of Longbridge - and how the scheme is a key part of that renewal.
"Our Government has supported the scheme since 1997 and the NHS trusts concerned have invested millions in much-needed infrastructure and site-enabling works," said Coun Drinkwater.
"A great deal of work is already under way but we are aware that HM Treasury is currently considering the scheme and we implore you to bring this matter to a speedy and successful resolution."
Any further time delay, she adds, "will inevitably mean more cost to the taxpayer".
"We would urge you to avoid any additional costs by backing the New Hospital Project now."