Two "dangerous" patients were on the run from a secure Birmingham mental health unit last night.
Marcus Carter and Nathan Gillespie escaped from the Reaside Clinic in Rubery.
Police urged people not to approach the pair who need medication and were described as "potentially a danger to themselves and others".
They said Carter, aged 19, from Longbridge, and Gillespie aged 21, from Low Hill in Wolverhampton, are believed to have escaped together from the clinic in Reaside Drive, Rubery, last Wednesday night.
Police said extensive searches of addresses and locations in Birmingham and Wolver-hampton had failed to trace the pair, who were last seen at about 10pm on December 7.
Insp Michael Brown, of Bournville Lane police station, said the men's disappearance was causing increasing concern.
"The men have not gone missing before," he added. "We urge them to come forward and contact police, the clinic or their families so that their safety and welfare can be vouched for and so they can be returned for their continuing treatment."
Carter is black, 5ft 10ins tall, of slim build with brown eyes and cropped black hair.
He was last seen wearing a red overcoat over a grey or blue zip-up top and blue tracksuit bottoms.
Gillespie is white, 5ft 8ins, of slim build with blue eyes and short, blond hair.
He was wearing a hooded top and dark coloured tracksuit bottoms.
Information to 0845 113 5000.