Pakistan's top-order problems continued as Northamptonshire ripped through the tourists after tea on day one at Wantage Road.
Openers Salman Butt and Imran Farhat were both dismissed for four as the under-fire pair were shown no mercy by bowlers Ben Phillips and Charl Pietersen.
Both batsmen's places in the Test side are under threat with returning vice-captain Younis Khan expected to get the nod for next Thursday's second Test at Old Trafford.
Butt in particular will be disturbed by his form after losing his wicket in the opening over for the second consecutive game following his first-ball dismissal in the first Test.
Pietersen claimed Butt's wicket with the fourth ball of the innings, as the opener tickled one through to wicketkeeper Riki Wessels, and the score had reached 24 when Farhat drove at a Phillips delivery and found the hands of Northants centurion Stephen Peters at backward square leg.
Taufeeq Umar looked impressive as he notched 29 at quicker than a run a ball, but David Wigley found the edge and Wessels took his second catch to leave the tourists teetering on 50 for three.
The only good news for Pakistan was the return of Younis Khan, who finished the day on 50 not out, alongside Faisal Iqbal (seven), as the tourists closed on 97 for three.
Earlier, Northants had racked up 269 for three with the declaration coming following the dismissal of opener Peters for 142.