Manchester United paid a heavy price for their cruise into the Champions League group stage draw as Gary Neville was ruled out for five weeks with a groin injury.
The setback, suffered just ten minutes into United's handsome win in Budapest, rules Neville out of England's World Cup double-header with Wales and Northern Ireland next month, leaving Sven-G^ran Eriksson seeking a suitable replacement.
Neville's injury will not do much for Sir Alex Ferguson's squad either as the season begins to take shape and vindicated the Scot's long-held fears over a surface on which Wes Brown suffered a broken ankle only three years ago.
The injury overshadowed a clinical display from the Red Devils. Gabriel Heinze has impressed with the quality of his defending since arriving from Paris St Germain last summer.
The tough-tackling Argentinian has never previously been seen as a goal threat, yet he remedied that with two excellent headers either side of half-time.
With Kieran Richardson firing home the goal of the night not long after Heinze had doubled his tally, the visitors were able to match their 3-0 first-leg victory margin, even if Neville's injury tempered their celebrations somewhat.
Everton will have to settle for a place in the Uefa Cup instead of the Champions League after a battling display at the El Madrigal Stadium.
Mikel Arteta cancelled out Juan Pablo Sorin's opener for Villarreal, but the Spanish side scored a second in added time through Diego Forlan to seal a 4-2 aggregate win.
Goals from Thomas Buffel and Dado Prso eased Rangers' passage into the group stage. The 2-0 win added up to a 4-1 aggregate victory over Cypriot outfit Anorthosis Famagusta.