Ministers could be hauled in front of Birmingham MPs to explain what they are doing for the city.
Richard Burden (Lab Northfield) has joined fellow Labour back-benchers in calling for regional sessions of the House of Commons.
These would allow MPs from regions such as the West Midlands to question members of the Government about their policies.
Scottish and Welsh MPs already have their own special sessions in the Commons, known as Grand Committees, where they are able to scrutinise the way Government policy affects their nations.
But there is nothing similar for English regions, even though the official West Midlands region has a larger population that Scotland.
MPs from across the country have demanded regional Question Times in a Commons motion.
They said: "Millions of pounds of Government money is spent every year in each of the English regions and major decisions are taken by Ministers without effective scrutiny."
The MPs call on the Government "to establish Grand Committees for each of the English regions and for Question Time sessions to be introduced in the House for each region, so that members can discuss in more detail issues relating to their locality and Ministers can be made more accountable to the region."
Mr Burden said: "We have the Grand Committees for Scotland and Wales. We also have select committees for Government departments such as transport.
"But there is no way of directly examining what the Government is doing for our region.
"It would help us lobby Ministers to make sure we were getting a fair deal."
He made the suggestion as Ministers are consulting on plans to create city regions, based around cities such as Birmingham, which could take over responsibility for policies such as transport, planning and economic development.
Conservatives are proposing English sessions of Parliament, in which MPs representing Scotland, Wales or Northern Ireland will be barred, to make decisions about English health, education and police services. Labour has condemned the policy.