The Met Office's new £80 million complex in Exeter is to produce the majority of forecasts, the Government has announced.
Production will move from a number of centres, including Birmingham, to the futuristic new building. The Met Office transferred its operation from Bracknell, near London, to Exeter in 2004.
Defence Minister Don Touhig said high-tech forecasting and modern communications had improved the Met Office's forecasting capability, which could now be mainly provided from one central location.
"This enables forecast production to be moved from the other centres - in Birmingham, London, Belfast, Cardiff and Manchester - to Exeter," he said.
"Aberdeen will continue to provide services to the UK commercial marine community, in particular the oil and gas industry, retaining their forecast production facility," said Mr Touhig.
In addition, forecast advisers for Public Weather Services, as well as Marine and OpenRoad services, will be based at Aberdeen, Manchester, London and Cardiff.
By restructuring forecast production, the Met Office said it would be able to deliver improved services to the public and focus on growth for commercial business.
Met Office chief executive Mark Hutchinson said there would continue to be a regional presence, across the UK.
But Prospect, the union representing 1,300 scientists, forecasters and other staff at the Met Office, said the decision to withdraw forecasting production from the UK regions would result in lost skills and expertise and have a "detrimental effect on its commercial business".
Weather service centralisation in Exeter would mean closure of civil weather facilities at Met Office centres at Cardiff, Belfast, London, Manchester and Birmingham.