Don't tell Gary Mills that lightning never strikes twice.
Having seen his Tamworth side suffer an undeserved FA Cup exit to Burton Albion in October, the Lambs manager witnessed another battling performance ending in heartbreaking fashion as a last-minute Aaron Webster winner earned the Brewers a 2-1 victory in their fourth round clash.
Mills said: "It was deja vu. It was similar to when they beat us in the FA Cup earlier in the season but we created more chances this time."
Blue Square Premier promotion-chasers Burton had taken a 29th-minute lead at the Pirelli Stadium when former Tamworth midfielder John McGrath fired home a 25-yard free kick past wrong-footed goalkeeper Phil Palethorpe.
Only the woodwork denied McGrath heading home a second goal but, with Matty Williams and Anthony Robinson becoming more of a threat, Tamworth grabbed an equaliser shortly after half time.
Gareth Sheldon curled in a corner and Chris Nurse powered home a header from inside the six-yard area.
Both sides had late chances when Shaun Harrad's shot struck the post for Burton and Tamworth substitute Nick Wright was denied by keeper Kevin Poole but there was more drama a minute from time.
Darren Stride headed Michael Simpson's free kick into the danger area and Webster nodded home.
Kidderminster Harriers also left it late before Iyseden Christie's last-minute goal secured a 2-1 win at Hinckley United.
A much-changed Harriers team, who included Jeff Kenna for the first time since September 22, struck first at Marston Stadium when James Constable tucked home a pass from Matt Barnes-Homer on 25 minutes.
But the Knitters recovered to level through Owen Story eight minutes before half time, and the game swung their way again when Harriers skipper Stuart Whitehead was sent off for fouling Walsall loanee Harry Harris as the last man ten minutes after the break.
Harriers, however, snatched victory when Christie held off his marker to drill a low shot into the net. They will now face Rushden & Diamonds at home in the fifth round.
Two-goal substitute Brian Quailey sparked Nuneaton Borough's last-gasp fightback to topple Blue Square Premier side Altrincham 2-1 at Liberty Way.
Alty led three minutes after half time with Chris Senior's well-taken strike following Jake Sedgemore's clever lob but Quailey equalised with a thumping 25-yard volley from Connor Franklin's header four minutes from time.
Three minutes into added time, Quailey bagged the winner, deflecting home a cross-shot from Andy Brown.