Edgbaston Priory's Vicky Botwright, the top seed, has been forced to withdraw from this week's British National Squash Championships in Manchester.
The Manchester-born world No 5 aggravated a foot injury in a women's World Tour event in the USA last week.
"I'm very sorry and extremely gutted that I am forced to pull out of the Nationals." said Botwright.
"I have a foot/heel problem that got worse when I was playing in New York at the weekend.
"I am having treatment on the injury and, while I would love to be a trouper and push through for myself and the Manchester supporters, I am being sensible and thinking ahead for the events that I have in the Commonwealth Games, which is my main focus."
Sussex's defending champion, Linda Elriani, takes over from the 28-year-old as top seed for the Championships which start tomorrow at the National Squash Centre at Sportcity in Manchester. Lincolnshire's Tania Bailey is elevated to second seed.
The Botwright family's disappointment at Vicky's withdrawal will no doubt be tempered by the news that younger sister Rebecca Botwright is now promoted to a seeded position in the revised draw.
The 24-year-old becomes the No 8 seed and will now face a qualifier in the first round.