Financial difficulties facing Birmingham's hospitals will be raised with Health Secretary Patricia Hewitt today.
Labour MPs have a private meeting to raise concerns over hospitals including Good Hope, in Sutton Coldfield.
But one Birmingham MP said she would urge the Health Secretary to take a tough line on over-spending managers.
Gisela Stuart (Lab Edgbaston) said: "I hope she will tell managers they need to live within their means."
Regional hospitals have been forced to cut services to make ends meet.
Good Hope will close two wards, losing 50 beds, and an operating theatre, to save £21 million a year. Managers warn it could rack up debts of £47.5 million.
The health trust funding Coventry's Walsgrave Hospital has warned it may have to make cuts of £29 million over 12 months.
Coventry Teaching Primary Care Trust, which pays for GPs and NHS dentists as well, said the figure was a worst case scenario.
Hospitals in Shrewsbury and Telford, in Shropshire, Stoke, in Staffordshire, and Nuneaton, in Warwickshire, are also heading for hefty deficits.
A BBC survey this week predicted the NHS would be £760 million in the red by the end of the month. Ms Hewitt predicted the deficit will be over £200 million.
But Ministers point out NHS funding has shot up since 1997, and will have tripled to £90 billion by 2008.
Ms Stuart said: "Hospital managers have to live within their means just like anyone running any other organisation.
"If the subject of deficits comes up at the meeting, which I expect it will, this is what I will say."
Fellow city MP Siôn Simon is to urge Ms Hewitt to help Good Hope balance books.
He said: "I will be asking the Secretary of State to investigate the situation.
"If financial help from the Government is needed, then I hope Ministers will be willing to see it is provided."