Scientists at the Solihull-based Forensic Science Service have been told job cuts affecting 200 staff will take place by the end of May.
The leading crime-fighting service, which helped catch Soham killer Ian Huntley and paedophile Roy Whiting, employs 1,600 people across the country and is due to close in March 2012.
It is believed members of the Solihull-based DNA unit are among the 200 posts under threat by the end of the month.
One scientist who works at the FSS at Birmingham Business Park said: “It isn’t a surprise, we all knew we would be going at some point.
“However, we were also told scientific staff would be among the last to go to ensure continuing full support for the UK criminal justice system.
“Personally, I am more of an optimistic realist in this situation, I would love to keep the job I have enjoyed doing but I also know that the decision was made and it had to happen at some point.”
He added many of those who had been offered redundancy lived in and around Birmingham, and included 200 staff across the service.
The decision to axe the FSS came after it emerged it was losing £2 million a month despite its pioneering work supporting police investigations.
Its pending closure has sparked a campaign to save the service, with leading forensic scientists warning the justice system would suffer without it.
A spokeswoman for the FSS confirmed negotiations over jobs were taking place.
She said: “Some people were told on Friday there is a possibility they will be leaving the business by the end of May.
“It is part of the progressive winding down.”
The FSS was unable to confirm which staff would be the first to leave and said details were yet to be confirmed.
She added: “It’s very much dependent on the business need.”