The world's first test tube baby, Louise Brown, is pregnant.
Louise, aged 27, who married former bank security officer Wesley Mullinder, aged 36, two years ago, is due to give birth in January.
The ex-postal worker from Bristol said it was a "dream come true". The couple started trying for a child after their marriage in September 2004.
Her husband said: "We are so excited about becoming parents, and I know that Louise will make a fantastic mother. We are already beginning to think about getting the house kiddy-proof."
Louise's birth on July 25, 1978, created headlines throughout the world and followed a decade of research on finding ways to fertilise human eggs outside the body.
She was born by caesarean section at the Royal Oldham Hospital thanks to the efforts of Dr Robert Edwards, who jointly invented the IVF technique that led to her birth, and the late Dr Patrick Steptoe, a gynaecologist at the hospital.
The two men successfully removed a single ripe egg from the ovary of Louise's mother, Lesley, and fertilised it in a glass dish with sperm from her husband.
The resulting embryo was implanted back into Lesley's body, and she became pregnant.