A family of five, including three young children, died when their car burst into flames in a horrific motorway crash.
The tragedy happened less than two hours after a man died in a crash on the same stretch of the M6 in Cheshire. A Portuguese lorry driver in his mid-40s was arrested after the second crash on suspicion of causing death by dangerous driving.
The driver, who worked for a Spanish firm, was being questioned by police.
The three children were in a car with two adults - thought to be their parents - when they were involved in a crash with three lorries and a second car on the north-bound carriageway.
The family's car caught fire and those inside died at the scene between junction 16 at Barthomley and junction 17 for Sandbach at about 10.40pm on Monday night, police said.
Superintendent Jed Manley of Cheshire Police said: "The collision involved three heavy goods vehicles and two other cars.
"As a result of the collision one of the cars tragically caught fire and all the occupants of that vehicle were killed."
The earlier fatal crash happened slightly further north just before 9pm.
A male driver, in his 30s, died when his white van hit a bridge parapet between junctions 17 and 18. Traffic tailbacks built up on the north-bound carriageway after the first crash.
The north-bound stretch of the motorway through Cheshire remained closed until around 7.20am on Tuesday.
There was another crash on the M6 at 5am on Tuesday when a car travelling north crossed the central reservation and hit a van heading south, a spokesman for the Highways Agency said.
Nobody is thought to have suffered serious injuries in the crash which happened between junction 15 for Stoke-on-Trent in Staffordshire and junction 14 (Stafford North).
The spokesman said there had been heavy rain in Cheshire until about 9pm.
The M6 deaths followed an earlier crash in Derbyshire in which three people, including a 12-year-old girl, died.
The girl, a rear seat passenger in a Volkswagen Passat, suffered severe injuries and was pronounced dead at Derbyshire Royal Infirmary.
Two men in a Vauxhall Corsa were pronounced dead at the scene of the crash, near Kirk Langley, Derbyshire.
The Vauxhall Corsa and Volkswagen Passat were travelling in opposite directions when they were in collision at about 8.55pm yesterday.
The female Passat driver suffered serious injuries and remains in hospital.
A six-year-old child who was in the Passat suffered less serious injuries, police said.