Lancashire are weakened in their pace attack while Nottinghamshire have a full complement to choose from for the first time this season in the Division One starting at Trent Bridge today.
Andrew Flintoff will not play again this season because of his ankle injury, James Anderson has a stress fracture of the back and Sajid Mahmood is likely to play for England in the second Test against Pakistan.
All-rounder Steven Croft comes in for Flintoff while Oliver Newby - left out of t he defeat by Kent - replaces Mahmood.
Mal Loye has been passed fit following a slight abdominal strain while Gareth Cross stays as wicketkeeper in the absence of Luke Sutton (broken thumb).
Bottom side Nottinghamshire have Andy Harris returning after missing the draw with Hampshire -Greg Smith makes way - in a four-man seam attack alongside Ryan Sidebottom, Charlie Shreck and Mark Ealham.
Hampshire have Billy Taylor in their squad to play Yorkshire at the Rose Bowl but fellow seamer James Bruce is recovering well from a shoulder problem but is short of full fitness. Kevin Pietersen is on England duty.
Tim Bresnan and Adil Rashid, who took 13 wickets between them for Yorkshire in the innings victory over Warwickshire, will not play. Bresnan has a back injury while legspinner Rashid is on England Under-19 duty. Chris Gilbert and Mark Lawson replace them.
An England call-up for Jamie Dalrymple has denied Middlesex of their off-spinning all-rounder against Durham at Lord's.
He is replaced by Chad Keegan, although if England release Dalrymple he is likely to play some part as a substitute.
Ben Harmison, brother of England pace ace Steve, will make his county championship debut for Durham. The 20-year-old, who has scored a century in each of his two first-class matches, replaces Gordon Muchall or Gary Scott while James Lowe comes in for Jon Lewis at the top of the order.