The first of a series of weekend major engineering works will mean a section of a key London to Scotland rail route will close this Saturday and Sunday.
The work on the West Coast Main Line (WCML) at Rugby in the West Midlands will mean there will be no direct Virgin Trains' services to and from Euston station in London over the weekend.
All Virgin Trains services from the Midlands, north west England and Scotland will terminate at either Birmingham International or Coventry stations.
A replacement coach service will run in both directions between Birmingham International and Northampton. This will connect with a train service running in both directions between Northampton and Euston, serving also Milton Keynes Central and Watford Junction. The train service will be three trains an hour on Saturday and two an hour on Sunday.
Services between the North Wales coast and Euston will run in both directions between Holyhead and Crewe only.
Network Rail (NR) has said there will need to be a number of weekend closures on parts of the WCML in order for the major upgrade of the line to be completed by December.
The Office of Rail Regulation (ORR) last week approved NR's new plan for completion of the work but said it would monitor the works' programme to ensure passengers were inconvenienced as little as possible.
Rugby was one of NR's Christmas and New Year engineering projects that overran, causing travel chaos and leading to ORR fining NR a record £14 million.