The BBC in Birmingham is set to lose around a quarter of its staff as part of proposals to save hundreds of millions of pounds a year.
The Factual Unit - which makes programmes such as Gardeners' World and the Hairy Bikers - will move to Bristol with jobs also going from radio, current affairs and news operations.
In total, the headcount in Birmingham will fall from 600 to about 450. Nationally, the corporation is set to shed 2,000 jobs by 2016.
However, popular radio drama The Archers will continue to be produced in the city, as will TV dramas Doctors and Land Girls, at the Drama Village in Selly Oak.
The BBC is also intending to spend more with the independent sector.
Despite the major cutbacks, a spokesperson for the BBC said there were currently no plans to leave the BBC’s city centre home at the Mailbox.
Speaking for the BBC in Birmingham, David Holdsworth, Controller of English Regions - who is based in the city - said: “Of course today’s news is sad for staff in Birmingham.
"Saving 20 per cent was never going to be easy. But we have taken these steps to ensure that we can continue to deliver high quality programmes for our audiences in Birmingham and elsewhere in the country.
"The BBC currently employs over 600 people in Birmingham; after these changes we will still employ over 450 staff here.
“The drama village is already home to two very successful dramas – and we have another in the pipeline, to be announced later this year. Together with The Archers, these programmes alone represent a substantial investment in drama made in the city.
"We will increase the West Midlands share of the BBC’s spend with the independent sector. The BBC will continue to play a strong role in the creative economy of the city alongside the independent sector; ITV; commercial radio and the new Creative England Midlands hub.”
There are currently 92 production and editorial staff who will be affected by the move to Bristol with around 60 per cent being offered the opportunity to relocate with the rest facing potential redundancy, although a spokesperson suggested there may be other “opportunities” within the corporation.
Programmes that will no longer be made in Birmingham include Countryfile, Gardeners' World and all other Royal Horticultural Society programmes, such as the Chelsea Flower Show, Coast, Hairy Bikers, See Hear and the Sky At Night.
In terms of local radio there will be a new emphasis on programme sharing with all-England programming after the drive-time show.
While there is unlikely to be little significant change in the BBC’s local current affairs and news output, there will be a reduction in resources with about 50 jobs under threat from local radio and news, which could include up to 11 from Radio WM.
Output from the Asian Network also faces being halved.
Radio shows set to move from the city include the Food Programme, Farming Today and Costing the Earth.
The spokesperson said the rationale behind the move, beyond the corporation’s need to find 20 per cent savings, was to create an “in-house powerhouse” of factual programming across the centres at Bristol and Cardiff.