Around 1,000 jobs are set to be axed through the closure of two sites operated by logistics giant Wincanton, union leaders have said.
The GMB said 450 jobs will be lost at Trafford Park in Manchester and a further 550 at Gloucester through a merger with another logistics firm, Culina.
The two sites are used to deliver goods to supermarkets.
Eddie Gaudie of the GMB said: "We are consulting with Wincanton regarding the Trafford Park and Gloucester sites, but 1,000 jobs are now set to be lost.
"We are opposing these closures and we want to use the consultation process to explore all reasonable alternatives."
Shadow work and pensions secretary Chris Grayling said: "The news on job cuts at Wincanton is a further blow to Manchester and Gloucester and is a further worrying sign that the Government's policies on the recession just aren't