Wage subsidies for firms taking on young workers are to be brought forward in areas with the highest levels of long-term youth unemployment, including some in the West Midlands.
Deputy Prime Minister Nick Clegg announced that instead of coming in at nine months, the subsidy of £2,275 per person will start at six months.
The subsidy, equivalent to half the minimum wage, is part of the Government's £1 billion Youth Contract launched last autumn.
Mr Clegg will tell a CBI jobs summit in London on Wednesday: "Three months can make all the difference.
"When you feel like your banging your head against a brick wall, when you live in an area where opportunities are already few and far between, another 12 weeks of rejection letters, of being cut off, of sitting at home waiting, worrying, that can seriously knock the stuffing out of you, making it extremely difficult to pick yourself up.
"So jobcentres will be able to make use of the subsidy before people are referred to the Work Programme, capitalising on their links with local employers, and they'll also intensify support, so more training, more regular coaching, spending more time with young people to knock a CV into shape or prep ahead of an interview."
CBI director general John Cridland will tell the summit that businesses and Government should do more to give people the skills and opportunities they need to get jobs. "Youth unemployment has been rising since 2004, so it's clear that a return to growth alone will not be enough to tackle the underlying causes of the problem.
"Today's young people are entering a complex world, and are making choices from the age of 13 that will define what they will be able to do with their lives. We ask a lot more of them in making their way in the world than was asked of previous generations.
"The result is sharp divides between the haves and have-nots, and across generational lines. As employers, we can and should step up to give all of our young people the support they deserve."
Mr Clegg will publish a list of youth unemployment hotspots, covering 20 local local authority areas with the highest rates of long-term youth unemployment which will be targeted with "renewed urgency" by the Government. Areas in the West Midlands included in the list are Wolverhampton, Sandwell, Walsall, and Birmingham.