Business leaders from the West Midlands and Milton Keynes will meet tonight to find ways both can benefit from the super city plans for the south.
Government plans to increase housing in Milton Keynes, sparked controversy last year as some claimed a new 'super city' would swipe Birmingham's business, jobs and second city status.
Now representatives from the West Midlands Business Council and Milton Keynes' MK Business Leaders plan to meet to discuss ways for both regions to benefit from the expansion.
WMBC chairman, John Hart, said the West Midlands could not ignore the new development.
"We in business have to use this opportunity to make this work for jobs and prosperity in the West Midlands region," he said.
"There are real possibilities of joint ventures."
Peter Muir, chairman of MK Business Leaders, said: "Business does not recognise administrative boundaries.
"We believe by working across boundaries, we can develop business opportunities for all and leverage economic activity across a much wider area."