Royal Bank of Scotland said today that it was consulting unions over plans to cut up to 9,000 jobs in the next two years - of which 4,500 will be in the UK.
The bank, which is now 70% owned by the Government, is cutting the roles from its backroom staff under plans to save £2.5 billion over the next three years.
RBS added that the actual number of jobs lost was likely to be "significantly lower" due to natural turnover, fewer agency staff and voluntary redundancies.
Unions reacted with outrage to the latest job cuts from the bank, which had to be bailed out with £20 billion from the taxpayer last year and racked up a UK record loss of £24.1 billion in 2008.
Rob MacGregor, national officer at trade union Unite, said the news was "truly devastating".
"Unite is appalled that thousands of people, who form the backbone of the RBS operations, are to be made redundant.
"These employees are totally blameless for the current position which RBS is in, yet they are paying for the mistakes at the top of the bank," he said.
The job will go in RBS's group manufacturing division, which provides support for the bank's customer-facing businesses, which include back office operations, purchasing, IT services, and property management.
As of the end of 2008 the division employed 45,000 people worldwide, including 27,000 in the UK.