Luxury goods group Waterford Wedgwood - owner of Midlands-based Royal Doulton - has revealed plans to axe 615 jobs across the UK.
The shake-up comes during a black period for job losses across region, including the collapse of MG Rover, job losses at Jaguar and proposals which could lead to hundreds of Birmingham dairy jobs disappearing.
The Waterford plans are part of a huge restructuring programme which will result in 1,800 jobs going globally and the closure of the firm's world-famous crystal plant in Dungarvan, Ireland.
A spokesman for Waterford said around 150 positions had "gone or would go" in the Stoke area - but he dismissed reports that the majority of the 650 UK jobs would be lost at the Potteries base.
He said the Stoke works remained crucial to Waterford and 2,000 jobs remained.
In terms of the Royal Doulton integration, Waterford said savings would be achieved in manufacturing, retail operations, administration and warehousing.
The company said it expected to cut the jobs in the Stoke area by the end of the rolling Royal Doulton integration programme.
In Ireland, a major factor in the closure of Dungarvan had been the site's need for substantial capital investment.
The cut glass will instead be made at a more modern facility at Waterford City, where the company employs around 1,000 people.
Amid falling demand from the United States, Waterford recently said like-for-like sales had dropped six per cent in the year to the end of March. It is also facing increased competition from lower-cost economies in Asia.
Chairman Sir Anthony O'Reilly said the moves represented a "bold but necessary restructuring programme".
The news comes as a deal looks an imminent deal which could see one of Midlands' most famous dairies sold - placing 330 city jobs at risk.
Midlands Co- operative Society is close to agreeing to sell its regional dairy arm to St Ivel Gold group Dairy Crest in a move likely to see production transferred from its ageing Vauxhall plant in the west of the city.
A Dairy Crest spokesman confirmed that it was expected that milk production would be transferred from Birmingham to its existing facilities, which include a plant in Fenstanton, Cambridgeshire and one in Stonehouse, Gloucestershire.
The business community and workforce is trying to pick up the pieces after the collapse of MG Rover, which was placed into administration with the loss of 5,000 jobs after its proposed Chinese partner SAIC pulled out of a potential rescue deal.
Earlier, Peugeot announced cutbacks at Ryton in Coventry - axing the plant's weekend shift, with the loss of 850 jobs, just a year after the night shift was ended at the expense of 700 workers.