The Government must do more to free business of damaging red tape - and hold back plans to increase tax, the president of the CBI will say tonight.
John Sunderland will make his comments at the CBI Annual Dinner in London, attended by around 1,200 business leaders.
He will share a platform with Chancellor Gordon Brown, who will be making his first major speech since the General Election.
Mr Sunderland will say: "As the Labour Party Business Manifesto said: 'Business has a responsibility to make profits'. And we want the freedom to do just that.
"Business is the major source of wealth creation in our society. We still provide most of the jobs, most of the taxes which fund our public services and all the profits which support our pension funds and savings.
"It is therefore an essential responsibility of Government to nurture business and the profits it generates."
Mr Sunderland will also say that the first key test of the new Government's business credentials will be the vigour with which it opposes the EU Working Time Directive.
"An individual's right to work, when and how they choose, should be inalienable.
"How on earth did we get to a position when my right to work, when and for how long I choose, could become illegal?"
The CBI is encouraged by recent comments from Tony Blair, describing the Working Time Directive as "wrong" and "completely misguided".
Mr Sunderland will also call on the Government to honour its commitment not to increase further business taxation.
"You have assured business that you have no intention of adding further to the significant taxation burdens which have already been imposed on business over the last eight years - an incremental £43 billion.
"Be certain, we'll hold you to that assurance," he will warn.
On public sector productivity, Mr Sunderland will say: "If you take the money, then please spend it well. We are entering a critical era in the relationship between Government and business.
"Business wants to contribute to a fairer society. But we need the freedom to operate, the infrastructure to compete and the liberty to make the profits to pay for a fairer world."