West Midland-based radio presenters and journalists at Smooth Radio could face the axe when the local station becomes part of a single national service broadcast from Manchester.
Smooth Radio West Midlands’ parent company GMG Radio, part of the Guardian Media Group, said it would create one Smooth Radio service broadcasting across the country and on the brand’s five FM stations in England.
The merger means a reduction in staff across the UK of up to 50 jobs with programming and news jobs at Smooth’s headquarters on the Hagley Road under threat.
Presenters working from the Birmingham base include Carlos and Tammy Gooding.
A spokeswoman for GMG Radio said: "Our hub for the station will be Manchester so regrettably there will be some redundancies in the news and programming departments."
There would be some sales presence retained in the West Midlands, she said, adding there would not be a clear picture of how many redundancies there would be in the region until consultations had taken place.
The group of stations already shares much of its content nationally, but pointed to recent regulatory changes in the Digital Economy Act which allowed it to go ahead with a final merger.
Smooth Radio had already started taking cost-cutting measures last year, axing several of its locally-produced programmes and transferring its weekend news broadcasts to Manchester.
The merger comes after Guardian Media Group earlier this month reported a pretax loss of £171 million for last year, a figure which included a £63.9 million write-down from GMG Radio.
Despite this, GMG Radio still posted an operating profit of £600,000 for the year.