Work has started on the first phase of the £100 million regeneration of the former Selly Oak Hospital site.
Regional builder Charles Church South Midlands, part of the York-based Persimmon group, has now started on site following the completion earlier this year of the deal to bring new life to the 43-acre plot.
The hospital there closed down following the launch of nearby Queen Elizabeth Hospital in 2010.
The £20 million first phase will comprise 98 houses built with an arts and crafts theme which Charles Church said was designed to reflect the local history and unique situation of the site.
There will also be a new cricket pitch and pavilion as part of phase one which is being branded 'The Oval'.
Andy Peters, managing director of Charles Church South Midlands, said: "These are very exciting times for Selly Oak and we are investing £100 million into the regeneration of this iconic site, with around £20 million on this first phase.
"These new homes at The Oval will be available for purchase from November and we are already experiencing a high volume of enquiries even before a single brick has been laid."
The site is on land off Acacia Road and Raddlebarn Road and is close to both Selly Oak and Bournville stations.
It was previously owned by University Hospitals Birmingham NHS Foundation Trust and the overall project, which was granted permission in 2013, is expected to contain 650 homes, shops, restaurants and office space.