Part of the Jewellery Quarter "in desperate need of regeneration" is set for a third residential scheme in a year.
Plans for 100 flats at 20-25 Legge Lane have been given the go-ahead, despite concerns over a lack of parking, after council planners said that part of the city was in dire need of improvement.
The proposals will see a row of decrepit buildings, once earmarked for a new food school to be run by University College Birmingham, part-demolished and restored.
It follows two different schemes to build flats on the road as the return of city living continues apace.
Coun Bob Beauchamp (Con Erdington) told Birmingham City Council's planning committee: "I personally think this is a very good development.
"I am pleased we're looking at the construction because it is quite a tight road and the area is very congested."
Chief planning officer Richard Gouldborn said: "This is in desperate need of regeneration. This is an innovative scheme, it's got a green roof on it, it's in the right scale and reflective of the Jewellery Quarter. There is always going to be a challenge with parking."
The project has been designed by Digbeth practice D5 Architects and will contain 67 one-bedroom and 33 two-bedroom units, no parking for vehicles but 104 spaces for bikes in a building reaching up to four storeys.
Documents accompanying the application said the plan was to demolish entirely one of the two buildings on the site and renovate the other.
The document added: "The evidence provided shows that the removal of the second structure and scale of new development proposed is essential to ensure the viability of the scheme.
"The proposals will enable a sustainable development that will have a regenerative impact on the area."
Pictures: CGIs and photos of planned Legge Lane flats
Coun Gareth Moore (Con Erdington) said he had concerns about the latest scheme because of a lack of parking.
He said: "There are already parking issues in the Jewellery Quarter and this has zero parking. It is going to exacerbate problems.
"I note it mentions a multi-storey car park 500 metres away. That's quite a walk, particularly at night, it's not a suitable location. More effort should be made to provide some car parking."
A council transport officer pointed out the authority was trying to encourage the use of car clubs for city centre residents and the developer was supporting that.
The vacant buildings have been neglected for well over a decade and have fallen into a severe state of disrepair but were placed on the market last year by property agency Knight Frank in bid to breathe new life into the site.
Romiga Holdings, a London-based property group also behind plans to build 73 flats at the former home of Eddie’s rock club near The Mailbox, is behind the project.
The plot, on the corner with Camden Drive, is opposite 3-5 Legge Lane where Stourbridge-based Kendrick Homes is planning to part-demolish and renovate the former Ashton & Moore anodising factory which dates back to the 19th century.
At the same planning committee meeting, it won approval to build four commercial units and a mix of 22 studios and one- and two-bedroom flats.
And finally in August, city property developer Court Collaboration announced it had secured a consortium of Chinese and Taiwanese investment to build 78 apartments on the pay and display car park and neighbouring land, also in Legge Lane.