Owned by Calthorpe Estates, the 27-acre former BBC site is currently being transformed to deliver more than 350,000 sq ft of medical and life science facilities.
The estate will include the new 172,000 sq ft dental hospital and school of dentistry, which is nearing completion, and a 150,000 sq ft private hospital to be run by CircleHealth.
Bilfinger GVA will provide full ongoing facilities and property management services across the estate and also act as joint letting agency alongside Colliers International.
Director Guy Thompson said: "We are immensely proud to work alongside Calthorpe Estates on this prestigious new development.
"The scheme is a major triumph for the city and we are excited to be appointed to manage a site which has so much history for Birmingham and such a bright future.
"We will be working hand-in-hand with Calthorpe Estates and all the site stakeholders at Pebble Mill to ensure the high standards are upheld and we will focus our attention on creating a vibrant and safe working environment within the attractive public realm."
Work on the access routes in and out of the estate and the first phase of the associated public realm will be completed in September.
Construction of the final phase of the public realm, including the ecological corridor alongside the Bourn and Chad Brooks, and a tranquillity garden are due to complete by the end of this year.
Ralph Minott, director of development at Calthorpe Estates, added: "Pebble Mill is part of Birmingham's world class healthcare cluster and presents an attractive offer for occupiers in clinical expertise and healthcare.
"This is a very exciting time for Pebble Mill with the first building to be delivered since 2001 nearing completion and the infrastructure and public realm now ready to be opened alongside the impressive dental hospital and school of dentistry.
"We are looking forward to continuing our work with Bilfinger GVA, who have been in instrumental in the smooth running of the scheme strategies for the delivery of the public experience, and strengthening our positive working relationship."