Companies in Birmingham are struggling with the costs of gas, electricity and oil although many are trying to minimise the impact, according to Birmingham Chamber of Commerce and Industry (BCI).
The chamber's latest research followed a claim by leading utility consultants that companies are needlessly being forced into receivership through energy costs.
Forty per cent have employed consultants or in-house energy experts to reduce utility consumption and 80 per cent have invested in energy-efficient technology.
All the businesses surveyed scrutinise bills for potential errors and dispute anything unusual.
The majority of large utility user businesses also negotiate contracts.
Charlotte Ritchie, policy executive at BCI, said: "Chamber members are well informed about the ways they can reduce the impact of high utility costs.
"The steps that businesses can take to significantly reduce their energy bills are quite limited, time consuming and costly. This survey has shown that businesses are already doing their utmost to lessen the burden, but many are still being crippled by soaring energy prices.
"The percentage of total business spend now allocated to energy costs in some industry sectors has drastically increased and energy is now seen as a priority even where it is not the core business.
"We simply cannot afford for our businesses, particularly our energy intensive manufacturing companies, to be competitively disadvantaged over energy costs.
"The Government must do all it can to support our businesses, including providing incentives to become more energy efficient.
"Tax breaks would certainly benefit those businesses investing in energy efficiency and we also need greater research and investment into new energy efficient products.
"We also have a responsibility to ensure that businesses have a secure and sustainable energy supply in the long term."