Around 22,000 runners are expected to descend on Birmingham city centre this Sunday for the 2015 Morrisons Great Birmingham Run.
The annual event, which this year features a new headline sponsor, is a sister race to the 10K road run which took place in May.
Organisers are urging runners and spectators to use public transport wherever possible as the city centre is expected to be very busy, especially with the road closures.
The first closure will see part of Granville Street shut from 8am on Saturday morning but the others will commence at 4am on Sunday morning.
In a change from 2014, the race will start in Jennens Road outside Birmingham Metropolitan College because of the ongoing roadworks around Paradise Circus island.
Elite competitors and the first group of runners will go off at 10.10am followed by three further waves until 10.48am.
As the map below shows, the course takes runners past Bullring and through Digbeth before hitting the Pershore Road to Bournville.
Participants will then loop around to start the run back towards the city centre, taking in Edgbaston Stadium, Cannon Hill Park and the dreaded hill up Lee Bank Middleway just after the ten-mile mark.
The finish line is once again half way down Broad Street, a short walk from the Library of Birmingham.
Among the celebrities who have signed up to take part are Philippa Tomson, from ITV's Good Morning Britain, Warwickshire cricketer Jonathan Trott and Olympic table tennis player Kelly Sibley.
Many companies across the city have also signed up to the Business Challenge will which see men's, women's and mixed teams take part in a bid to be named fastest firm at the event.
Full details of the road closures, along with downloadable maps and event guides, are available from greatrun.org/great-birmingham-run.