Environmental health officers say residents living in a proposed 22-storey apartment block in Broad Street will find it too noisy.
The council's own noise pollution investigators are urging councillors to refuse the planning application for the development on a car park at the corner of Sheepcote Street and Broad Street.
Warwickshire-based developer Regal wants to build the block, containing 189 one- and two-bedroom apartments and shops, cafés or restaurants on the ground floor.
A second element of the project would see an 18-storey Innside hotel again with retail, leisure and a restaurant.
The scheme, called 'Left Bank', also involves the partial demolition of the Grade II building at 78-79 Broad Street which currently houses the 'Big Bite' takeaway.
Seven years ago, Regal had wanted to build a 56-storey tower which would have been the tallest in the city but this ambition has now been scaled back.
The environmental health officers believe the street, with a thriving night-time economy and heavy traffic congestion, is simply too noisy and they will be inundated with complaints from the new residents.
A report prepared ahead of next Thursday's planning committee meeting said: "They recommend refusal of the application as they consider the site is not suitable for residential given the high noise levels from bars along Broad Street."
It added that, if the tower were approved, there would need to be strict conditions to ensure sealed windows and ventilation were provided to limit noise from the street.
Several heritage groups have also raised concerns about the impact of the tower on the three-storey arts and crafts style 'Bank' building next door, once home to Barclays.
Despite the objections, the planning committee is being urged to approve the project.
In a report to the committee, case officer David Wells said: "In principle, the proposed development is consistent with both local and national land use planning policies.
"A tall building in this location is acceptable and the design is to a good standard.
"Whilst the building would have an impact on the listed building, there are public benefits that outweigh the harm caused."