Independent bookshop chain Foyles has signed a deal to open a new outlet in the Grand Central shopping centre next to New Street station.
It will be Foyles' second shop outside of London following its launch in Bristol in 2011.
The shop, which will open in September alongside John Lewis and other retailers at the £150 million centre, will be 4,300 sq ft.
The store will be the chain's sixth and led by retail operations director Siôn Hamilton.
Chief executive Sam Husain said: "Grand Central Birmingham fulfils all of our criteria for a new store - a landmark retail destination with high footfall and a quality retail mix, including our neighbours John Lewis.
"We look forward to selling books to new customers in the West Midlands, whether they be local residents, visitors to Grand Central Birmingham or travellers passing through New Street station."