Birmingham's business leaders have said they are "disappointed" after a long-awaited inquiry into the future of Britain's airports called for a third runway to be built at Heathrow.
Paul Kehoe, chief executive of Birmingham Airport, urged the Government to "move ahead with caution" in response to the Airports Commission's recommendations.
The airport had opposed expansion at Heathrow and called on the Government to back a strategic network of long-haul airports throughout the UK instead.
And Greater Birmingham Chamber of Commerce said expansion of Gatwick, rather than Heathrow, would offer more chances for airports outside the south east like Birmingham Airport to expand.
After three years of investigation, the Airports Commission said Heathrow was best placed to provide "urgently required" capacity.
It chose a new, full-length runway at Heathrow rather than expanding one of the airport's current runways or building a new one at Gatwick.
The commission also recommended a "comprehensive" package of measures to make Heathrow's expansion more acceptable to the local community.
This includes a ban on night flights from 11.30pm to 6am, legally binding limits on noise, a new levy to fund insulation for homes, schools and other community facilities around Heathrow and an independent noise authority.
Commission chairman Sir Howard Davies said the conclusions were "clear and unanimous".
He warned that London's airports were showing signs of "strain" and the entire system would be full by 2040 without action.
The Government will now consider the recommendations but the commission said a firm decision was needed soon as bringing a new runway into operation would take at least a decade.
But Mr Kehoe said: "Given the significant levels of growth we have seen at Birmingham Airport within this period, especially in long-haul routes, we urge the Government to move ahead with caution so as not to damage the ability of regional airports to grow.
"The Midlands is a powerful engine of growth at the heart of our country and needs direct aviation to succeed.
"With our £200 million investment in the airport, including our runway extension allowing for this summer's extended series of direct flights to Beijing, we are doing all we can to support the region's businesses and leisure passengers.
"Whilst the Government continues to review all the evidence before it, Birmingham Airport looks forward to continuing the expansion of our long-haul offering in support of the region's economy."
Paul Faulkner, incoming chief executive of the Greater Birmingham Chambers of Commerce, added: "We are disappointed that Davies has missed the opportunity to encourage a network of regional airports.
"Concentrating everything at Heathrow now embeds an unwelcome monopoly for Heathrow and the airlines. The cost to fly will now only increase.
"The report creates a big inconsistency in the Government's strategy to rebalance the economy away from London. HS2 is consistent with this vital ambition. Davies, by putting all the aviation eggs in one basket, is not.
"It will not help job creation outside of the South East and this is one of the major flaws in the report.
"There is also the argument that many business people in the Midlands want local, direct flights for both passengers and freight and not to be forced to use London airports."
He added: "However, we can regard Sir Howard's recommendations as an opportunity for Birmingham Airport to take advantage while Heathrow continues to be at full capacity.
"At best, it is predicted a third runway at Heathrow would not be operational for at least ten to 15 years and, in the meantime, airlines will continue to look for airports in the UK like Birmingham which has huge potential for more capacity."
Environmental campaigner Friends of the Earth condemned the announcement.
West Midlands branch campaigner Chris Crean said: "This report vacillates over a false choice - expansion at Heathrow or Gatwick - when neither can be allowed if we're to stop runaway global warming.
"Building a new runway at Gatwick or Heathrow would have a hugely damaging impact on local people and their environment and would be a step backwards in UK efforts to tackle climate change.
"Airport expansion also risks worsening local air pollution levels which already breach legal limits.
"The UK will be a laughing stock if it turns up at crucial climate talks in Paris later this year, claiming global leadership while at home having nodded through new runways, killed its onshore wind industry and foisted fracking on communities that don't want it."