Gordon Brown was today accused of being the Government's "Monopoly" man.
Whatever progress business made the Treasury found a way of imposing a tax hit.
CBI president John Sunderland warned in his New Year message that companies were entering 2006 with "real uncertainty over key national issues", reflecting a sense of unease as major decisions loomed on the economy, pensions and energy in the first half of the year.
He said: "Businesses like clarity when planning future investment decisions, but there are a great many policy balls up in the air.
"If the Government drops any of these, British jobs and British competitiveness will suffer."
On the economy, he predicted that the 2006 Budget would probably be Mr Brown's most critical.
"Macroeconomic stability has been one of this Govern-ment's greatest achievements, but its foundation has been weakened during 2005, and the continuing creep of taxation has chipped away at competitiveness.
"It feels a bit like Monopoly - every time you reach your destination, the Chancellor has been there first and put up a Treasury hotel. Then you either have to pay up or you are out of the game."
Mr Sunderland went on: "Despite the Chancellor's raid on oil companies announced in his Pre-Budget Report - with all the harm that may do to investment in North Sea exploration - there remains a sizeable structural deficit in the Government's accounts.
"Trying to fix a £10 billion black hole through greater borrowing sounds like pouring more water into a leaky bucket and if that tap runs out the next could be another tax raid on business. Companies would feel more reassured if it saw the Government making real efforts to mend the bucket and slow the rate of public spending growth."
Mr Sunderland said the Government's decision on future pensions provision would be one of the defining decisions of the year.
Urging it to act on the recent Turner Pension Report outlining possible reforms, he again condemned the public sector deal which will allow existing civil servants to continue to retire at 60 though all new staff will have to work until they are 65.
"Lord Turner has challenged the Government to make fundamental decisions now, delivering long-term stability for tomorrow's pensioners.
"Unlike its deplorable choice on public sector pensions, it must make the decision that is right for Britain, not the one that is most politically expedient.
"In doing so, it must ensure that the settlement is fair. If employees are to get an opt-out from the proposals, then so must hard-pressed small firms."
On energy, Mr Sunderland urged the Government to be brave in making decisions in the long-term interests of the nation.
He said: "As we enter the coldest months of the year, we draw some comfort from the Government's commitment to a wide-ranging review of its position on energy.
"But if the big freeze arrives, some major UK companies still have no certainty on the short-term gas supplies they need to keep their production going. Meanwhile, costs are going through the roof. Businesses operating in the fourth biggest economy in the world, and those who work in them, deserve better than this.
"All UK businesses can hope for is that we leave 2006 with far more certainty over our long-term energy supplies. Will nuclear play a role, and if not, how will we replace the twenty per cent contribution it currently makes to our needs?"
Mr Sunderland said the Government should return to being the friend of business.
In a world where other countries were making major efforts to attract inward investment, the UK had to remain a competitive environment for international business.