One of Britain's leading human rights barristers' chambers which represented the Birmingham Six is to close as a result of the Government's "devastating" cuts to legal aid.

Tooks Chambers, which led by Michael Mansfield QC has represented the family of Stephen Lawrence and fought miscarriage of justice cases such as the Birmingham Six , said its dissolution was "a direct result of government policies on legal aid".

Justice Secretary Chris Grayling's policies were "cumulatively devastating the provision of legal services and threatening the rule of law", the London-based group said.

A statement on its website said: "It is with great regret that Tooks Chambers has decided to begin the process of dissolution.

"The dissolution of Chambers is the direct result of Government policies on legal aid. The public service we provide is dependent on public funding. Ninety per cent of our work is publicly funded."

Founded at the height of the miners' strike in 1984, Tooks barristers have been involved in a series of high-profile cases including the Hillsborough, De Menezes and Princess Diana inquests and the Bloody Sunday inquiry.

The Chambers will wind up operations on October 11 before being formally dissolved on December 27. Its barristers will continue to practise and represent their clients, it added.

Mr Mansfield and others are looking into developing a new model of working aimed at supporting publicly funded lawyers "committed to continuing the struggle for social justice", the Chambers said.

Mr Grayling has announced a raft of reforms to legal aid to save £220 million a year.

Among the changes, criminal defendants living in households with a disposable income of £37,500 or more will be stopped from automatically accessing legal aid, while prisoners' rights to the support will also be curbed.

In April, reforms to the Legal Aid, Sentencing and Punishment of Offenders Act (Laspo) came into effect, removing large areas of law from the scope of civil legal aid.

Mr Mansfield, who is representing the family of Mark Duggan, whose death sparked the 2011 summer riots across England, declined to add any further comment tonight while the inquest into Mr Duggan's death continues.

A Ministry of Justice spokeswoman said: "We have one of the best legal professions in the world but cannot close our eyes to the fact legal aid is costing too much. All businesses have to consistently innovate and adapt to changing circumstances to remain successful.

"At a time when major financial challenges are being felt by businesses and households across the country the legal sector cannot be immune from the Government's commitment to getting better value for every penny of taxpayers' money we spend."