The first female chief executive of Grant Thornton, a kidney consultant and European head change.org will all feature in a conference next month in Birmingham.
The trio are all speakers lined up for TEDxBrum 2016 which this year is themed on #PowerOfUs and aims to breakdown the walls and connect public, private and civic sectors to foster a better city together.
Sacha Romanovitch was appointed to the top job at financial services firm Grant Thornton last year, becoming the first woman to be elected as chief executive of a major accountancy practice.
She says her leadership is based on establishing a common purpose and liberating people to achieve that goal as well as focussing on creating sustainable value for clients, people and broader society.
Adnan Sharif is a consultant nephrologist at the Queen Elizabeth Hospital Birmingham, with a special interest in renal transplantation.
He is also the secretary of Doctors Against Forced Organ Harvesting which campaigns against illegal and unethical organ procurement around the globe.
Also lined up to speak is Simon Willis, European managing director of online petition service change.org which now claims to have 140 million users.
Mr Willis has also been chief executive of social innovation charity The Young Foundation and worked for the Government in various roles including head of financial crime.
Among the performers at the conference are Kathak dancer Vidya Patel and charity The People's Orchestra.
Around 800 people are expected to attend the event, which takes place at Town Hall Birmingham on June 11, to share skills, ideas and resources.
Event curator Imandeep Kaur said: "This year's event really is shaping up to be the best yet. With every year, we aim to be more ambitious and push the boundaries of what's possible and TEDxBrum 2016 is no exception.
"This year's theme aims to showcase the best of Birmingham and encourage a collaborative approach to making a difference across our city and beyond."
Tickets can be purchased from Town Hall Birmingham.