The first tenants have been signed up at the new Imperial & Whitehall offices at The Grand in Colmore Row.
Commercial insurance firm CNA Hardy has agreed a ten-year lease while landscape architecture practice Node Urban Design has taken space on a five-year deal.
Making up the new tenants at the landmark Birmingham building are Surge Recruitment which has agreed a three-year lease.
CNA Hardy, which opened its fifth UK office in Birmingham last year, is relocating from 43 Temple Row to bigger premises due to the ongoing expansion of the business while Node is moving from Innovation Court in nearby Edmund Street.
The Grand is owned by Hortons' Estate which has invested more than £1.5 million in refurbishing the office suites as part of the wider renovation of the former hotel building following years of inactivity.
Management surveyor Nina Meeks said: "Since launching Imperial & Whitehall earlier this year, we have received lots of positive feedback and a huge amount of interest from potential occupiers.
"The investment we have made in redesigning and refurbishing the office suites is being justified and we're pleased to welcome CNA Hardy, Node Urban Design and Surge Recruitment as the first new occupiers at the building and look forward to announcing further lettings in the near future."