Budget airline Norwegian is scrapping all of its flights to Spain from Birmingham Airport.
The firm said it would cease operating routes to the popular holiday destination from this weekend as part of a review of its services.
Norwegian operates routes to five destinations in the country - Barcelona, Gran Canaria, Madrid, Malaga and Tenerife.
A statement from the company said: "Following a review of our services, we will cease operating flights from Birmingham to Spain with the last services departing on Saturday, October 28.
"A natural part of our UK development will see some reductions in routes with lower passenger demand, allowing us to focus instead on providing affordable flights on strong-performing routes."
This is the latest service to stop operating from Birmingham Airport, following similar decisions in recent months by both United Airlines and American Airlines to cease running routes to New York, while Emirates has reduced the frequency of its service to Dubai.
Earlier this month, Monarch Airlines went bust, signalling an end to several services out of Birmingham including to Valencia, Split, Naples and Rhodes.
And in July, new Irish carrier Aer Southeast scrapped its planned service between Birmingham and Waterford before a single plane had left the tarmac because it had failed to secure a tour operator's licence.