New direct daily flights between Birmingham Airport and New York will run from next spring.
American Airlines will commence the flights on May 8 to John F. Kennedy Airport with the route expected to provide nearly 100,000 seats a year.
It will complement the existing route between Birmingham and Newark operated by United Airlines.
Through the American Airlines and British Airways joint business and oneworld airline alliance, they will offer a British Airways code share, allowing customers to earn and redeem BA air miles and Avios points.
Birmingham Airport chief executive Paul Kehoe said: "This new route will not only create more capacity to this vibrant US business and tourist destination, it will also broaden connectivity and choice from the Midlands with American Airlines across North America and Canada and see the return of a British Airways flight code to Birmingham.
"Last year, the West Midlands exported £4.5 billion worth of goods to North America and has the largest trade surplus with North America of any UK region, and with global brands such as JLR, JCB, Cadbury and Kraft trading both locally and in the US, this is an important link for Midlands' business.
"The region is also a major tourist destination for Americans, with attractions such as Stratford, Warwick and Birmingham drawing in thousands of visitors every year so we look forward to welcoming many of these tourists into Birmingham next summer and thank the team at American Airlines for recognising the region's vast market opportunities."
The American Airlines flight will operate daily, arriving from JFK into Birmingham at 7.10am and depart for the return leg at 10am.
Suzanne Boda, American Airline's senior vice-president for Asia, Canada and Europe, said: "Adding Birmingham to American's growing global network is an exciting development.
"Tourists from the US will have closer access to a wide range of attractions in the Midlands while business travellers will also be rewarded with greater choice when flying across the Atlantic.
"Departing passengers from Birmingham will have direct flight to New York, one of the world's most renowned business and leisure destinations, while connecting passengers will have excellent access to key business and leisure markets up and down the East Coast.
"We look forward to starting this new route in 2015 and I'm confident of its success."